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KMID : 0360319950270050846
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Journal of Korean Cancer Research Association
1995 Volume.27 No. 5 p.846 ~ p.856
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Adjuvant Chemotherapy with '5-Fluorouracil Olus Low-dose Leucovorin' Following Surgical Resection of Stage II, III Colon Cancer
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이재환
김태원/최종수/장대영/변호영/김성배/김상위/서철원/이규형
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Abstract
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Objective:
@EN About seventy-five percent of the individuals with colon cancer will have a primary surgical resection with the hope of complete tumor eradication. Despite the high resectability rate and a general improvement in therapy, nearly half of all
patients
with colon cancer still die of metastatic tumor. Over the past three decades, many clinical studies have failed to demonstrate benefits from adjuvant therapy. Recently, new data from several studies have demonstrated delays in tumor recurrence
and
increases in survival for specific groups of patients. The objective of this study was to evaluate the effectiveness of '5-fluorouracil(5-FU) and low-dose leucovorin' in reducing the recurrence rate and improving the survival of the patints with
surgically resected colon cancer in stage Ⅱand Ⅲ.
@ES Methods:
@EN One hundred and fifty six with surgically resected colon cancer in stage Ⅱand Ⅲfrom Nov 1989 to Dec 1993 were included in this study and were divided into two groups. First group(LF arm) included eighty five patients who received
combination
chemotherapy of '5-FU and low-dose leucovorin' following resection of colon cancer, and second group(control arm) included seventy one patients who received only oral UFT(r) or no adjuvant treatment. '5-FU 400mg/m*, intravenously, on days 1-5
every
4
weeks for 6 cycles.
@ES Results:
@EN 1) There were significantly more recurrences and distant failure in control arm than LF arm.
2) The estimated 4-year disease-free survival was 82.5% in LF arm and 59.8% in control arm(p=0.007).
3) The estimated 4-year overall survival was 94.3% in LF arm and 63.9% in control arm (p=0.001).
4) The survival differences between LF arm and control arm were significant in stage Ⅱand Ⅲrespectively.
5) Number of metastatic lymph nodes, histologic differentiation, and whether or not patients received 5-FU/leucovorin chemotherapy, were each found to have prognostic significance.
@ES Conclusion:
@EN This study strongly suggests that '5-FU and low-dose leucovorin' adjuvant chemotherapy is effective in patients with surgically resected stage Ⅱand Ⅲcolon cancer.
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KEYWORD
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